A Red Shifted Variant Of Channelrhodopsin Allows Deep...

Lin, J.Y., Magne Knutsen, P., Muller, A., Kleinfeld, D., Tsien, R.Y. (2013) ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation. Nature neuroscience, 16 (10), 1499-1507. This paper focusing on a res-shifted variant of Channelrhodopsin shows that using red light can improve transcranial excitation because of the properties of red light. Red light is less scattered by tissue and is absorbed less by blood than previously used wavelengths. This development is very important for the potential use of optogenetics in chronic studies to treat neurological disorders, as cranial windows can be avoided. The opsin created is called ReaChR and has a spectral response to light at wavelengths greater than†¦show more content†¦Raimondo, J.V., Kay, L., Ellender, T.J., Akerman, C.J. (2012) Optogenetic silencing strategies differ in their effects on inhibitory transmission. Nature neuroscience, 15(8), 1102-1104. It is important to know that optogenetic silencers can have different effects on synaptic transmission. For example, a light-driven inward Cl-pump, NpHR, causes changes in the reversal potential of the membrane potential of GABA receptors causing a spike after illumination. Arch, also an inward Cl- pump, on the other hand does not result in a spike after illumination. This article provides useful insight of light-activated proteins that can be used as modulators. The ability to change GABA membrane potential can be extremely useful when working with Parkinson models since these receptors are involved in some of the Parkinson’s symptoms. Tà ¸nnesen, J. et al. (2011) Functional Integration of Grafted Neural Stem Cell-Derived Dopaminergic Neurons Monitored by Optogenetics in an In Vitro Parkinson Model. PlosOne, 6(3), 1-10 Intrastriatal grafts of stem cell-derived dopamine neurons induce behavioral recovery in animal models of Parkinson’s disease. This could possibly be used in non-animal models, however previously it was unknown how these transplanted grafts integrated in the host circuitry. By using optogenetic activation of grafted cells and inhibition of host neurons, Tà ¸nnesen and colleagues were able to

An Impartial Perspective on Personal Philosophy Essay Samples

An Impartial Perspective on Personal Philosophy Essay Samples The True Meaning of Personal Philosophy Essay Samples I am able to learn to be an active listener when it has to do with important info. Unlike another type of essays, personal essays are somewhat more flexible and versatile. To secure more reliable outcome, it's highly recommended that you consider independent reviews. They have sites that offer direct contacts between writers and customers and permit them to discuss details and get the ideal result. It is possible to also acquire several discounts on our site which will help you to save some more money for future orders or anything you want to spend them on. After some moment, you are going to be in a position to cover future orders with the accumulated amounts. These samples will allow you to accomplish the endeavor. The sample essay outline samples are useful for a big amount of people chiefly those who want to compose an essay on a particular topic. The cost of an essay rides on the total amount of effort the writer has to exert. But he's also known for being the father of contemporary Western philosophy. In fact, the majority of philosophers specialize in studying in 1 time period and its connection to philosophy. Employ a professional writer and get your non-plagiarized essays, law term. The ideal way to ascertain the Personal Philosophy of Success is to realize the definition of succeeding. Philosophy of life will differ between each individual. Philosophy of education can likewise be regarded as a normative theory in education. My Personal Philosopy My Personal Philosophy A teacher's individual philosophy of education is a crucial element in their approach to guiding children along the course of enlightenment. This advice might help you identify a dependable firm. Fortunately, we're here to provide a dependable group of expert writers with all the relevant skills necessary to develop the best essays on political philosophy essay topics and a lot more. One other important strategy that I've included to my private philosophy is being focused on my future objectives. One of the success strategies that I've incorporated inside my private philosophy is flexibility. There's solution to any challenging endeavor. The human wants, therefore, have a tendency to be dynamic and unlimited. Contrary to other academic disciplines philosophy is a complicated topic which requires the student to submit a paper that's both exemplary and relevant. And this isn't the close of the story yet. While it's not feasible to find a person to write you a paper at no cost, it's possible to acquire the philosophy of religion essay topics written for you cheaply. Knowing about the outlines and formats for a variety of kinds of essays is an excellent way to augment the way in which you prefer to state your opinions. The on course textbook has showed me steps about how to control a prosperous life in addition to a personal life. The philosophy of life essay examples you will find should help you choose the ideal alternative for yourself. Our primary goal is to be certain that we address all of your essay writing needs. This statement can be quite hard to write as you must locate the perfect'' words to describe how you're feeling about education. You should have your reasons, and our primary concern is that you wind up getting an excellent grade. On the other hand there's not anything wrong with getting assistance from a great consultant on the right outline format. Understandably, you might find it challenging to have a dependable business to provide the very best example of philosophy in life essay at a pocket-friendly pace. In my definition, being success means that you may reach and accomplish your targets or what it is you are dreaming. As is true with issues like political philosophy essay topics, you're predicted to inquire into the ethical nature of various societies and how each individual fits into it. By visiting our site, you will discover an illustration of philosophy in life essay that you're able to utilize to understand the grade of work we can deliver for you.

Notre dame free essay sample

Notre-Dame de Paris French for Our Lady of Paris, also known as Notre-Dame Cathedral or simply Notre-Dame, is a historic Catholic cathedral on the eastern half of the Ile de la Cite in the fourth arrondissement of Paris, France. The cathedral is widely considered to be one of the finest examples of French Gothic architecture and among the largest and most well-known church buildings in the world. The naturalism of its sculptures and stained glass are in contrast with earlier Romanesque architecture. As the cathedral of the Archdiocese of Paris, Notre-Dame is the parish that contains the cathedra, or official chair, of the archbishop of Paris, currently Cardinal Andre Vingt-Trois. The cathedral treasury is notable for its reliquary which houses some of Catholicisms most important first-class relics including the purported Crown of Thorns, a fragment of theTrue Cross, and one of the Holy Nails. In the 1790s, Notre-Dame suffered desecration during the radical phase of the French Revolution when much of its religious imagery was damaged or destroyed. An extensive restoration supervised by Eugene Viollet-le-Duc began in 1845. A project of further restoration and maintenance began in 1991. Notre-Dame de Paris was among the first buildings in the world to use the flying buttress(arched exterior supports). The building was not originally designed to include the flying buttresses around the choir and nave but after the construction began, the thinner walls (popularized in the Gothic style) grew ever higher and stress fractures began to occur as the walls pushed outward. In response, the cathedrals architects built supports around the outside walls, and later additions continued the pattern. Many small individually crafted statues were placed around the outside to serve as column supports and water spouts. Among these are the famous gargoyles, designed for water run-off, and chimeras. The statues were originally colored as was most of the exterior. The paint has worn off, but the gray stone was once covered with vivid colors. The cathedral was essentially complete by 1345. The cathedral has a narrow climb of 387 steps at the top of several spiral staircases; along the climb it is possible to view its most famous bell and its gargoyles in close quarters, as well as having a spectacular view across Paris when reaching the top. The design of St. Peters Anglican Cathedral in Adelaide, Australia was inspired by Notre-Dame de Paris. NOTRE-DAME CATHEDRAL HISTORY Notre-dame that means â€Å"our lady† is dedicated to Mary, mother of god and is one of the most visited and notable monuments in Europe. There are 37 representations of Mary in the cathedral. The cathedral is about 850 years old and is located on the small island in the middle of Paris surrounded by the Seine called Ile de la Cite. The construction started with the first stone being laid 1163 by Maurice de sully and king Louis VII encouraged the big project, it was completed 1345, with other words the construction of the cathedral took about 200 years to finish. Notre-dame has had a long and certainty interesting history, at one point 1431 the English king Henry VI was crowned inside the cathedral. Notre-dame has witnessed some great events in French history 80 kings, two emperors, 5 republics and two world wars. Before crusaders went on â€Å"holy-wars† the used to pray at the site of the cathedral for Mary to protect them during the war. Some parts of the Church was destroyed during the 17th century and some parts were found in 1970 in the â€Å"latin quarters† almost 200 years later, intact. 1786 geographers decided that all distances in France should be measured from Notre-dame. During the revolution the church was used as an storage for food and stable for horses. During the 17th century the Cathedral was in so bad shape it was nearly demolished, but Napoleon decided to reconstruct and rebuild the Cathedral and was later crowned emperor of France 1804 by pope Pius VII inside the newly rebuilt cathedral with its 8000 pipes of the Cathedrals grand organ. 1831 we met for the first time Quasimodo the fictional person Victor Hugo created and wrote about in his book â€Å"the hunchback of Notre-dame†. Which is about the ugly Quasimodo with a hunchback and his impossible love to the beautiful girl Esmeralda. That later became a Disney movie. During 1871 the cathedral almost burnt down by the communards but survived almost unscathed. During the Second World War all of the glass windows were taken out of the cathedral due to the rumors that German soldiers would destroy the newly renovated new glass windows. The reconstruction of Notre-dame took 23 years  to finish. One of the windows called the â€Å"Rose window† had a special archeological value because it was the biggest window produced in the 13th century. When the Second World War ended General de Gaulle rushed to the cathedral to pray in thanksgiving. 1991 a ten-year program of maintenance and restoration was initiated. DEVELOPMENT AND CHANGES DURING THE 200 YEARS Maur ice de Sully was bishop of Paris from 1160 to 1196. He provided to rebuild a cathedral church dedicated to the Virgin Mary (Notre-Dame) and making it a bishop’s church, a canon church and a baptistery. Notre-Dame’s first stone was laid in 1163 in the asset of Pope Alexander III. The new building was included the new art movement as the gothic style. The first unknown builder began with a double side aisle plan without a salient transept ,a four story construction with tribunes, large, 32. 5 metre sexpartite arches, predominantly horizontal lines, original archwork in the curved part of the deambulatory, alternating strong and weak pillars between the first and second aisles. In 12th– early 13th Century ; The construction was managed by four major builders: 1163-1182 : construction of the choir and its double deambulatory. The choir’s high altar was given on 19 May 1182 by Henri de Chateau-Marcay, the Papal legat, assisted by the bishop Maurice de Sully. 1182-1190 : construction of the last three bays in the nave, the side aisles and the tribunes. 1190-1225 : edification of the facade courses and the first two bays in the nave, connection of the two bays to the upper facade and the Gallery of Kings. 1225-1250 : upper gallery and two towers on the facade, modification and expansion of the upper windows and fitting out the nave side chapels between the flying buttresses abutments. In the late 13th – early 14th Century ;The builders were Jean de Chelles, Pierre de Montreuil, Pierre de Chelles, Jean Ravy, Jean le Bouteiller. Transept arms were extended as North counter-brace (Cloister Portal and North Rose Window) and South counter-brace (Saint-Etienne Portal and South Rose Window). Construction of the choir chapels and the apse between the buttresses. Installation of the large flying buttresses in the choir and the 15-metre apse. Erection of the tribune and a historiated stone screen around the choirand the sanctuary. Changes in the 17th and 18th Centuries; The sanctuary and the choir were renovated by Robert de Cotte . South Rose Window was restorated. The 12th and 13th century stained glass windows with white windows was replacement in the mid-18th century by the Le Vieil brothers. The new sacristy and Central Portal were created by Soufflot. All the major portal statues was destroyed and 28 statues was destroyed from the Gallery of Kings during the Revolution. In the early 19th century; The government of King Louis-Philippe I decided to the restoration of the Paris cathedral and the construction of a sacristy in 1844. The restoration project was given to Eugene Viollet-le-Duc and Jean-Baptiste Lassus. In 1857, after the death of Lassus, Viollet-le-Duc was the only sole builder. in this period,the Spire was rebuilt. The sculptures were restored by fifteen sculptors. The new sacristy was built. New windows were installed by master glassworkers ( Alfred Gerente, Louis Steinheil, Antoine Husson, Marechal de Metz, Didron the Elder). The central portal was renovated to the pre-Soufflot state. Part of the Treasury and the furniture were reconstituted. Also wall paintings in the side chapels were changed. The great organ was repaired. Modern Period; There was an intense debate over whether to replace the nave’s 19th century grisaille windows with coloured windows in 1965. In the end, master glassworker Jacques Le Chevallier was selected to make these windows, non-figurative grisailles with splashes of colour. The great organ, which in the 20th century became the world’s most famous, underwent major restoration work done by a group of French organ builders in 1990 to 1992. There is a major cleaning work on the west facade since 2000. The last changes, made in 2004, led by cardinal-archbishop Jean-Marie Lustiger, the passage between the two transepts was consolidated. STRUCTURE Notre-Dame de Paris’s structure is one of the oldest in Paris, along with Saint-Pierre de Montmartre Like most of French cathedrals, Notre-Dame de Paris is based on the form of a Latin cross. The nave has ten spans, the choir five spans. The axis is slightly deviated to the left (North) with respect to the axis of the nave. The apse is semi-circular in five sections. The nave is flanked by double aisles which are extended by a double ambulatory, all with side chapels (except the first three bays) and radiating (29 in total, with a total of 37 bays quadrangular). The structure of cathedral is obviously Gothic. It is based on flying buttresses and buttresses. These buttresses were introduced in 1175, to take the vaults of the aisles. Notre Dame de Paris was among the first buildings in the world to use the flying buttress (arched exterior supports). The building was not originally designed to include the flying buttresses around the choir and nave. After the construction began and the thinner walls (popularized in the Gothic style) grew ever higher, stress fractures began to occur as the walls pushed outward. In response, the cathedrals architects built supports around the outside walls, and later additions continued the pattern. The elevation of the cathedral is the same as the first Gothic churches in France. It is based on a three-level floor. First level: Large pointed arches on columns Second level: Tribune communicating with the nave by three arches. Third level: high windows and a circular top Technically, the establishment of warheads required steep roofs, those of Notre-Dame de Paris is 55  °. In addition, the scarcity of large timber, due to land clearing and urban development at that time, made it necessary to use smaller wood and therefore lighter section that allowed the rise of timber and the accentuation of their slope. In the choir, there is a first frame with timber felled to 1160-1170 (it is estimated that some could have 300-400 years, which brings us to the eighth or ninth centuries! ). The first frame is gone, but the woods were reused in the second frame established in 1220. They are still there today. This wooden structure is based on a roof frame consisting of lead 1326 tables 5 mm thick weighing 210 000 kilograms. The eleventh and twelfth centuries, the roofs of churches flat tiles were covered because of abundant clay deposits. Paris, being away from such deposits, they preferred lead. ANALYSIS FACADE Elements Gothics The ogival or pointed arch, the ribbed vault and the flying buttresses, with these three elements revolutionized medieval Gothic architects construction. The ogival or pointed arch The use of the pointed arch plays a dual role: 1 built, reducing the lateral thrust allowing the development of lighter and daring constructions, 2 plastic, because it gives the buildings an aspect of verticality projection upwards.. typical of the Gothic style. Ogival vault The vault by a series of arcs that intersect with structural function is formed Brackets The Struts The pillars Capital H-facade Facade: The western or main facade has a perfect body balance horizontal and vertical lines. It is organized into three superimposed floors with two square towers at the ends. The horizontality is marked with three superposed: In the upper body an arcade is located, as a clerestory. The central level is occupied by windows and central rosette. The lower level is occupied by the three covers. The verticality is marked by two towers at the ends and finished in terrace. Delimiting the three bodies buttresses supporting the towers are located. First level (3 covers) Door of Santa Ana (South) A tympanum with a semicircular lintel with a slight pointing is observed. It is chaired by a Madonna with a child in her lap. At the top there are sculptures of angels and vegetable decoration. On either side are two separate censing angels. At the ends of the tympanum we find the figure of a bishop and a scribe and the opposite side a kneeling king. Door Judgement (central) At the top of a Christ with cruciferous nimbus Man appears showing the wounds of the hands. On both sides, two angels carrying the instruments of the Passion, while St. John and the Virgin intercede for mankind. In the central part is shown, from left to right, the blessed, looking to Christ, the Archangel Michael is weighing souls, with two demons who try to tip the scales in your favor. The convicts, bound by chains, are pushed by two other devils. The lower part shows the Resurrection of the dead to be judged by Christ. Dead out of the graves clothes for identification of their status or occupation, while angels at the ends touch the trumpets heralding the trial will begin. Door of the Virgin (north) At the top of the scene of the Coronation of the Virgin, who is seated next to the Almighty is sculpted. They are accompanied by angels, two kneeling at the ends, pose motivated by its location, and a third crowning the Virgin. In the center is the scene of the Dormition of the Virgin or death. Mary is lying on his bed, surrounded by the apostles and two angels who start lifting the Assumption. In the lower register, in place of the lintel, is representing the Patriarchs, flanking a canopy under which lies the Ark of the Covenant, containing the Tablets of the Law by which Yahweh established by the Old Law Moses, of great symbolic value. Second level Gallery of kings About 20 feet above the ground, a gallery with 28 statues rises above the portals. Each statue, 3. 5 meters high, represents the 28 kings of Judea who preceded the coming of Christ. Of the original medieval statues only fragments remain, as during the Revolution were destroyed by believing that represented French kings. Central portal on the large circular rosette, nearly 10 feet in diameter, one of the highlights of the stained glass facade stands. Above the rosette, a row of columns and then the two bell towers complete face west. The rosette is the symbol of Virgin Maria. On either side there are mullioned windows. Third level The third body is composed of two towers that house the bells. The total height of the towers is 69 meters. At the base of the towers Gallery of chimeras is observed. The origin of the gargoyles back to the Middle Ages and is related to the rise of the bestiaries and the torments of hell Gargoyles meet three basic functions: Drain rooftops. Were used for the drain of the cathedral, giving off water through the holes in the mouth of the sculpture Decorate these drains looking therefore an aesthetic purpose. Scare away witches, demons and other evil spirits. Measures: In addition to the plant in the form of a cross, the cathedral has a facade of 40 meters wide, a length of 130 meters and a maximum height of 69 meters. Contains 5 ships, 37 chapels, three rosettes with 13. 5 meter diameter each and a total of 113 windows. Made of white granite. DETAILS Organ Though several organs were installed in the cathedral over time, the earliest ones were inadequate for the building. The first noteworthy organ was finished in the 18th century by the noted builder Francois-Henri Clicquot. Some of Clicquots original pipework in the pedal division continues to sound from the organ today. The organ was almost completely rebuilt and expanded in the 19th century by Aristide Cavaille-Coll. The position of titular organist (head or chief organist) at Notre-Dame is considered one of the most prestigious organist posts in France, along with the post of titular organist of Saint Sulpice in Paris, Cavaille-Colls largest instrument. The organ has 7,374 pipes, with ca 900 classified as historical. It has 110 real stops, five 56-key manuals and a 32-key pedalboard. In December 1992, a two-year restoration of the organ was completed that fully computerized the organ under three LANs (Local Area Networks). The restoration also included a number of additions, notably two further horizontal reed stops en chamade in the Cavaille-Coll style. The Notre-Dame organ is therefore unique in France in having five fully independent reed stops en chamade. Bells The cathedral has 10 bells. The largest, Emmanuel, original to 1681, is located in the south tower and weighs just over 13 tons, and is tolled to mark the hours of the day and for various occasions and services, ringing in a resounding E?. This bell is always rung first, at least 5 seconds before the rest. Until recently, there were four additional 19th-century bells on wheels in the north tower, which were swing chimed. These bells were meant to replace nine which were removed from the cathedral during the Revolution and were rung for various services and festivals. The bells were once rung by hand before electric motors allowed them to be rung without manual labor. When it was discovered that the size of the bells could cause the entire building to vibrate, threatening its structural integrity, they were taken out of use. The bells also had external hammers for tune playing from a small clavier. On the night of 24 August 1944, as the Ile de la Cite was taken by an advance column of French and Allied armoured troops and elements of the Resistance, it was the tolling of the Emmanuel that announced to the city that its liberation was under way. In early 2012, as part of a â‚ ¬2 million project, the four old bells in the north tower were deemed unsatisfactory and removed. The plan originally was to melt them down and recast new bells from the material. However, a legal challenge resulted in the bells being saved in extremis at the foundry. As of early 2013, they are still merely set aside until their fate is decided. A set of 8 new bells was cast by the same foundry in Normandy that had cast the four in 1856. At the same time, a much larger bell called Marie was cast in the Netherlands—it now hangs with Emmanuel in the south tower. The 9 new bells, which were delivered to the cathedral at the same time (31 January 2013), are designed to replicate the quality and tone of the cathedrals original bells. Gargoyles : Notre Dames Gargoyles have been built around 1240. Their main purpose is to regulate and evacuate the rain water far from the walls, to avoid that they get dirty. They have got the shape of fantastic and monstrous creatures. At the beginning of Notre Dames building, there were less gargoyles and their shape was rougher. They also have an esoteric role which can be interpreted in different ways. This role is to keep evil creatures away from the cathedral, and also to remind that the good is inside the building. Another role could be the the purification image they offer by getting rid of soiled water. There are also a lot of Chimeras at the top of the cathedral, which are statues of fantastic creatures. They only have a decorative purpose and were built much later than gargoyles by Eugene Viollet-le-Duc. Inside the cathedral, the nave is surrounded by 14 side chapels built between the flying buttresses of the nave. Theses chapels are highly decorated by the Mays des Orfevres. These 76 paintings were offered by the goldsmith friary in the 17th century. The transept which is a transversal nave of the principal one give to the structure the shape of a cross. It also permit to reinforce the structure of the cathedral. In Notre Dame, the transept (14meters) is larger than the nave (12 meters).

One Direction Where We Are Tour Review free essay sample

Throughout my high school experience, One Direction has always been present in my life.I’m embarrassed to say that I know way too much about those five british boys. About five years ago, Harry Styles, Niall Horan, Zayn Malik, Louis Tomlinson, and Liam Payne all auditioned for the TV show â€Å"The X Factor† as solo artists until Simon Cowell decided their careers would skyrocket much faster if they were put together as a boyband. Since then, One Direction have come out with three albums, sold millions of records, and gone on three sold out tours. I have been to at least one show of each of their tours and I believe it’s safe to say that the most recent one they have been on, the Where We Are tour, has definitely been the best. Three weeks ago, I attended my fourth One Direction concert. Although I wouldn’t characterize myself as much of a fan anymore, I still had a fantastic time. We will write a custom essay sample on One Direction Where We Are Tour Review or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The concert took place at the Rose Bowl in pasadena which could not have been more convenient considering the Rose Bowl is a five minute drive from my house. The first opening act was a solo singer named Jamie Scott who I had never heard of until then. He was an adorable british indie singer who did a great job of blowing me away. All he did was sit on a stool but his pure talent made it quite the performance. I knew right about then that the night would be great. Next up on stage was an Australian pop-punk band called 5 Seconds of Summer. I have known and loved them for a bit over a year now because they toured with One Direction on their last tour. I knew about half of the songs they performed so the excitement really pumped me up for One Direction to come on. The set lasted about an hour but it seemed so much shorter because of the pure ecstasy they filled the crowds hearts with. Being a One Direction fan and being a 5 Seconds of Summer fan kind of goes hand in hand in the world of boybands. After those Australian cuties got off the stage, the night was really about to begin. The stadium was being filled with anticipation and excitement as the wait for One Direction started to come to a close. The ten second countdown stretched on for what seemed like an eternity. Finally, the boys took the stage. The screams from tens of thousands of girls resulted in the first song, â€Å"Midnight Memories,† barely being heard. Considering everyone knew all of the words anyway, that hardly mattered. Being in row 21, seat 9, really made the experience that much more unreal. Around ten feet to my left, there was a long runway that connected to the stage to allow the boys to get closer to the crowd. I was within throwing distance of the biggest current boy band in the world and I could not have had a better time. As the night went on, the show only got better. Those five twenty-something year olds each have a unique and beautiful voice. They found the perfect balance of slow songs and fast songs which gave everybody in the crowd something they enjoyed listening to. Each concert I have gone to, they have played different songs which only adds to the excitement. Before the concert, I was wondering which songs were going to be sung and I was extremely satisfied with the ones I heard. All of my expectations had been fulfilled and they truly outdid themselves. The main album featured in this tour is called Midnight Memories although they also featured songs from Take Me Home and Up All Night. In my opinion, the bests of the night were â€Å"Little Black Dress,† â€Å"Better Than Words,† â€Å"Kiss You,† and the closing song, â€Å"Best Song Ever.† Those select songs were filled with energy and pure joy from all five band mates and it was thrilling to see how much fun t hey were having up there on stage. Out of all the boy bands in todays era, I would say confidently that One Direction is my favorite. They seem to have so much personality and quirkiness to them compared to other similar bands. They will always have a special place in my heart for One Direction even if I’m not a diehard fan anymore. Every rose has its thorn, and this concert definitely did have some drawbacks. Parking for the event was highly expensive and it took around an hour to leave the parking lot at the end of the night. The last thing I wanted to do at 11 o’clock on a Thursday night was wait in traffic so that aspect of the show was definitely not the best. I definitely still did enjoy the show but on top of everything, having a sinus infection really did not help either. I tried to forget how stuffed up I was and enjoy the whole night but it resulted in me coughing and sneezing everywhere. In my opinion, it was all worth it because when I think back on it, I don’t think about how sick I was or how incredibly annoying parking was, I think about how much fun I had when the music was playing. If I had to rate the concert from 1-10, I would definitely give it a 9. The drawbacks really did not have a strong impact on how great that night was. It may not be something you think would appeal to you, but you would be surprised by the amount of fun you might have. This band appeals mostly to teenage girls but I think that if anyone would really give them a chance, they might just find themselves dancing and singing along when they are driving alone in their car. It was event not to be missed and I cannot wait for my next opportunity to see One Direction live.